News Wire

Positive efficacy results have been reported from a phase 2b trial (ZAF-203) evaluating beloranib (Zafgen), a MetAP2 inhibitor, in the treatment of severe obesity complicated by type-2 diabetes. The study achieved its primary efficacy endpoint, as treatment with 1.8-mg and 1.2-mg doses of beloranib…
Positive results have been reported from an analysis of long-term follow-up data from a phase 2 study of MultiStem stem-cell therapy (Athersys, Inc.) in patients with ischemic stroke. The data demonstrated that MultiStem-treated subjects continued to improve through one year and had a significantly…
As a safety measure against the emerging Zika virus outbreak, the FDA has issued new guidance recommending the deferral of individuals from donating blood if they have been to areas with active Zika virus transmission, potentially have been exposed to the virus, or have had a confirmed Zika virus infection.…
The FDA is alerting health care professionals of a voluntary recall of morphine sulfate 0.5 mg/mL preservative free in 0.9% sodium chloride, 1 mL syringe, CII, for intravenous use made and distributed by Pharmakon Pharmaceuticals in Noblesville, Indiana, because the product is super-potent. Pharmakon…
The FDA has granted breakthrough therapy status to durvalumab (MEDI4736, AstraZeneca) for the treatment of patients with programmed death ligand-1 (PD-L1)–positive inoperable or metastatic urothelial bladder cancer whose tumor has progressed during or after one standard platinum-based regimen. Durvalumab…
Experts at the National Institutes of Health conducted systematic reviews of the literature to address 57 clinical questions related to the treatment of patients with ankylosing spondylitis (AS) or nonradiographic axial spondyloarthritis (SpA). For patients with active AS, the authors strongly recommend…
In a study of patients entering a hospital for acute stroke, researchers have increased their understanding of an association between certain types of stroke and the presence of oral cnm-positive Streptococcus mutans. Robert P. Friedland, MD, a professor in neurology at the University of Louisville…
Countries coping with the Zika virus crisis should consider new ways to fight disease-carrying mosquitoes, including testing the release of genetically modified insects and bacteria that stop their eggs from hatching, the World Health Organization (WHO) has announced. “Given the magnitude of the Zika…
Russia’s health minister Veronika Skovortsova said on February 15 that an Ebola vaccine developed by her country during the last 15 months has shown encouraging results and would undergo further testing in West Africa, according to a report posted on the Medical Xpress website. “Phases 1 and 2 of…
The FDA has issued a complete response letter regarding supplemental new drug applications for ezetimibe (Zetia) and ezetimibe/simvastatin (Vytorin) for reducing the risk of cardiovascular events (i.e., cardiovascular [CV] death, nonfatal myocardial infarction [MI], nonfatal stroke, hospitalization…
The phase III ARCADE study of darbepoetin alfa (Aranesp, Amgen) has met its primary endpoint of reducing the incidence of red blood cell transfusions in anemic patients with low- or intermediate-risk myelodysplastic syndrome (MDS) at the end of the 25-week study period. Darbepoetin also significantly…
In 2012, researchers at the University of California at Los Angeles (UCLA) set out to review thousands of electronic health records (EHRs) for a more accurate and less expensive way to identify people with undiagnosed type-2 diabetes. The team has now reported several previously unknown risk factors…
Health care providers in the U.S. are adopting a “better safe than sorry” approach to the current Zika virus outbreak, according to an article posted on the FierceHealthcare website. At the Cleveland Clinic in Ohio, for example, health care providers are closely watching daily updates about the…
Researchers at children’s hospitals across the U.S., including Baylor College of Medicine, the University of California–San Francisco, and the University of Colorado School of Medicine, have found that hospitals serving children may face financial penalties for patient readmissions due to factors…
Researchers have discovered that clonally expanded human immunodeficiency virus (HIV)-infected cells can persist and produce new virus over many years in patients receiving combination antiretroviral therapy (cART). Thus, any cure for HIV infection will have to attack these cells to permanently clear…

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