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A Bargain at $850,000? Luxturna Costs Less Than Predicted

Spark Therapeutics Inc. has priced its new gene therapy for a rare form of blindness at $850,000. That may not seem like much of a bargain, but it starts to sound better when you consider that the industry expected a cost of $1 million. The company said the price tag for voretigene neparvovec-rzyl (Luxturna)…
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Cosentyx Label Updated to Include Scalp Psoriasis

The FDA has approved a label update for secukinumab (Cosentyx, Novartis) that includes data on treating moderate-to-severe scalp psoriasis, a difficult-to-treat form of the disease that affects approximately half of all psoriasis patients. The label update is based on the results of a dedicated phase…
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FDA Advisory Panel Pans Tlando, a Testosterone Replacement

An FDA advisory committee has declined to recommend approval of a proposed new oral testosterone replacement therapy (Tlando, Lipocine Inc.). Lipocine said the Bone, Reproductive, and Urologic Drugs Advisory Committee (BRUDAC) voted six in favor and 13 against the benefit–risk profile of Tlando, which…
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Study Finds Psychiatric Medications Are Not Overprescribed for Kids

A new study at Columbia University Irving Medical Center (CUIMC) challenges the popular notion that psychiatric medications are overprescribed in U.S. children and adolescents. When the researchers compared prescribing rates with prevalence rates for the most common psychiatric disorders in children,…
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Vaccine Fails to Help CMV-Positive Stem-Cell Recipients

ASP0113 (Astellas Pharma Inc./ Vical Incorporated), an investigational DNA vaccine being developed for cytomegalovirus (CMV)-seropositive hematopoietic stem cell transplant recipients, did not significantly improve overall mortality and CMV end-organ disease through the first year following the transplant,…
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FDA Approves Nonopioid ZTlido Patch for PHN Pain

The FDA has approved a lidocaine topical system (ZTlido, Sorrento Therapeutics, Inc.), 1.8%, for the relief of pain associated with post-herpetic neuralgia (PHN) that Sorrento bills as “a major advancement in analgesics” because of improved adhesion. “ZTlido was designed to solve a problem that…
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Flu Claims the Lives of 22 More Children

The flu-related deaths of 22 more children were reported during the week ending February 10, federal officials say, bringing the pediatric toll to 84 for this grim flu season. Nearly 20,000 people have been hospitalized so far, with weeks to go. Several of the childhood deaths occurred weeks earlier…
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Cabometyx Extends Survival in Liver Cancer Study

Cabozantinib (Cabometyx, Exelixis, Inc./Ipsen) improved overall and progression-free survival among previously treated liver cancer patients in the pivotal phase 3 CELESTIAL trial, according to results being presented at the 2018 ASCO-GI Symposium in San Francisco. At the planned second interim analysis…
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Flu Season Continues to Worsen, CDC Reports

A U.S. map of flu activity issued Friday by the Centers for Disease Control and Prevention (CDC) was a sea of red: the color marking the highest levels of outpatient visits for an illness that continues to worsen this season. According to this week's CDC report, covering the week of January 7 to 13,…
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Positive Top-Line Phase 3 Results Announced for Migraine Treatment Ubrogepant 

Positive results have been announced from ACHIEVE I (UBR-MD-01), the first of two pivotal phase 3 clinical trials evaluating the efficacy, safety, and tolerability of Allergan’s orally administered ubrogepant 50 mg and ubrogepant 100 mg compared with placebo in a single migraine attack in adults.…
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Study Estimates Nonoptimized Medications Cost the U.S. $528.4 Billion Annually

Rising drug prices have gotten a lot of attention lately, but the actual cost of prescription medications is more than just the dollars and cents on the bill, according to a recent study. Researchers at the University of California San Diego (UCSD) estimate that illness and death resulting from nonoptimized…
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Xtandi Reduces Risk of Metastasis or Death by 71% in Prostate Cancer Trial

Positive results have been announced from the phase 3 PROSPER trial in patients with nonmetastatic castration-resistant prostate cancer (CRPC). The results show that the use of enzalutamide (Xtandi, Astellas Pharma/Pfizer) plus androgen deprivation therapy (ADT) significantly reduced the risk of developing…
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CDC Reports Rising Flu Hospitalizations, 16 More Pediatric Deaths 

Hospitalizations blamed on the flu may be on track for a record in this increasingly challenging flu season, federal officials said Friday, and 16 more pediatric deaths were reported during the week.  “This is a very difficult season. The hospitalization rate is the highest we’ve seen,” said…
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New Drug Capsule May Allow Weekly HIV Treatment

Researchers at Massachusetts Institute of Technology (MIT) and Brigham and Women’s Hospital have developed a capsule that can deliver a week’s worth of human immunodeficiency virus (HIV) drugs in a single dose. This advance could make it much easier for patients to adhere to the strict schedule…
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Roche Hemophilia Drug Lowers Costs Despite High Price: ICER

Emicizumab (Hemlibra, Roche Holding AG), a costly new drug to treat the bleeding disorder hemophilia A, could significantly reduce health care expenses for certain patients, according to a draft report from an independent U.S. nonprofit organization that evaluates clinical and cost effectiveness of…
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