Venous thromboembolism constitutes a clinical spectrum encompassing deep venous thrombosis (DVT) and pulmonary embolism (PE). These are responsible for substantial morbidity and mortality. An exciting advance in this area of medicine involves the outpatient treatment of stable patients with DVT. This therapeutic approach, which has been facilitated by the advent of low-molecular-weight heparin (LMWH) preparations, is the focus of this supplement. The economic impact of DVT outpatient therapy is also addressed.