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AstraZeneca has announced the results from the pivotal SOCRATES trial, which assessed the efficacy of ticagrelor (Brilinta) 90 mg twice daily compared with aspirin 100 mg once daily in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA). The primary efficacy endpoint of the…
Mount Sinai Hospital is the first center in the U.S. to use a new cancer treatment consisting of luminescent chemotherapy-filled beads injected into tumors through the wrist. The minimally invasive treatment, using M1 LUMI beads (BTG plc) filled with doxorubicin, is available for patients with inoperable…
Patients undergoing a coronary artery bypass graft (CABG) procedure could pay vastly different sums for the operation depending on where they have it performed, according to a new study published in the American Journal of Cardiology. Researchers at the University of Iowa found that prices for CABG…
Scientists at the University of Leeds in the United Kingdom have answered a 25-year-old question about how a family of proteins allows bacteria to resist the effects of certain antibiotics. Proteins of the ABC-F family are a major source of antibiotic resistance in “superbugs,” such as Staphylococcus…
Promising data have been reported from an ongoing phase 2 trial of Reolysin (Oncolytics Biotech), a proprietary formulation of the human reovirus, in combination with paclitaxel in women with ovarian cancer. The randomized study is comparing paclitaxel monotherapy with paclitaxel plus Reolysin in patients…
Thirty-six experts in the field of Duchenne muscular dystrophy have signed a letter to the FDA saying that, based on existing scientific data, the agency should approve eteplirsen (Sarepta Therapeutics), which is awaiting a final verdict. The letter was delivered to the FDA’s Division of Neurology…
Eagle Pharmaceuticals has received a complete response letter from the FDA for its ready-to-use, stable liquid intravenous formulation of bivalirudin (5 mg/mL in a 50-mL vial). The treatment is intended for use as an anticoagulant in patients 1) undergoing percutaneous coronary intervention (PCI) with…
Two studies in the phase 3 OCTAVE (Oral Clinical Trials for Tofacitinib in Ulcerative Colitis) program have met their primary endpoints. At week 8, a significantly greater proportion of patients receiving tofacitinib (Xeljanz, Pfizer) 10 mg twice daily (BID) were in remission compared with patients…
Singapore-based TauRx Pharmaceuticals has taken a slightly different approach to finding a treatment for Alzheimer’s disease (AD) than most other companies, according to a report posted on the BioSpace website. TauRx is studying LMTX, a second-generation tau aggregation inhibitor (TAI), in three international…
The FDA has announced a proposal to ban most powdered gloves in the United States. While the use of these gloves is decreasing, they pose an unreasonable and substantial risk of illness or injury to health care providers, patients, and other individuals who are exposed to them, which cannot be corrected…
Positive findings have been announced from a pivotal phase 3 trial of romosozumab (Amgen/UCB) in men with osteoporosis. The study met its primary endpoint, demonstrating a statistically significant increase in bone mineral density (BMD) at the lumbar spine (as assessed by dual-energy x-ray absorptiometry)…
Researchers funded by the National Institutes of Health (NIH) have discovered the cellular switch that boosts the activity of sperm cells so that they can travel to the egg. The finding may lead to new options for male contraception as well as treatments for infertility resulting from problems with…
Surgery has been the standard treatment for appendicitis for more than a century. Millions of appendectomies are performed annually in the world, more than 300,000 in the U.S. alone. Studies have been carried out over the years to determine whether nonperforated appendicitis could be treated with antibiotics…
When mutated, a gene known for its ability to repair DNA appears instead to cause breast cancer, scientists report. The gene, GT198, whether mutated by genetics, environmental factors, or both, has strong potential as a way to diagnose breast cancer early and as a new treatment target, said Dr. Lan…
 Scientists at Umeå Centre for Microbial Research (UCMR) have discovered chemical compounds that are able to attenuate the virulence of the bacterial human pathogen Listeria monocytogenes. Their findings were published in Cell Chemical Biology. The dramatic increase of antibiotic resistance makes…

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