New Evidence-Based Treatments for Depression

When depression is unrecognized and untreated, it can have negative consequences on medical resource utilization. Even when depression is treated, appropriate selection of pharmacologic therapy can make a difference in outcomes. This supplement, based on Magellan Behavioral Health’s 2001 Clinical Medical Retreat, addresses concepts in treatment and management of depression, including a discussion of drug-product selection based on differential efficacy and compelling considerations about antidepressant medication interactions.


  • Depression’s Ripple Effect on Health Status and Costs
  • Overview of Antidepressant Therapy
  • Antidepressant Drug Interaction Considerations
  • Using Pharmacoeconomic Data To Compare Antidepressant Therapies
  • The Texas Medication Algorithm Project for Major Depression
  • Cost-Effective Therapy: Translating Evidence Into Practice