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Nearly 4 out of 5 hospitalized children receive medications that have been tested and approved only in adults, according to a study in the Archives of Pediatric and Adolescent Medicine. Pediatric Health Information Systems Research Group performed the study in 31 tertiary hospitals. The adult-approved drugs most prescribed for children were central or autonomic nervous system drugs (specifically morphine), anti-infective agents, and fluids and electrolytes, says the principal investigator, Anthony D. Slonim, MD, of Children's National Medical Center in Washington D.C. "If 80 percent of hospitalized kids at academic pediatric hospitals use drugs off label, then that's a significant amount," says Slonim. Much more study is needed, researchers add.
Central and autonomic central nervous system drugs
Cardiac and adrenergic agents
Fluids, nutrients, and GI agents
Endocrine and metabolic agents
Hematologic, biologic, and immunologic agents
Respiratory tract, and eye, ear, nose, and throat agents
Percentage of discharged patients who received the drug
Percentage of patients who received the drug off label
Source: Shah SS, et al. Off-label drug use in hospitalized children. Arch Pediatr Adolesc Med. 2007;161:282–290.
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