News Wire

Singapore-based TauRx Pharmaceuticals has taken a slightly different approach to finding a treatment for Alzheimer’s disease (AD) than most other companies, according to a report posted on the BioSpace website. TauRx is studying LMTX, a second-generation tau aggregation inhibitor (TAI), in three international…
The FDA has announced a proposal to ban most powdered gloves in the United States. While the use of these gloves is decreasing, they pose an unreasonable and substantial risk of illness or injury to health care providers, patients, and other individuals who are exposed to them, which cannot be corrected…
Positive findings have been announced from a pivotal phase 3 trial of romosozumab (Amgen/UCB) in men with osteoporosis. The study met its primary endpoint, demonstrating a statistically significant increase in bone mineral density (BMD) at the lumbar spine (as assessed by dual-energy x-ray absorptiometry)…
Eagle Pharmaceuticals has received a complete response letter from the FDA for its ready-to-use, stable liquid intravenous formulation of bivalirudin (5 mg/mL in a 50-mL vial). The treatment is intended for use as an anticoagulant in patients 1) undergoing percutaneous coronary intervention (PCI) with…
Two studies in the phase 3 OCTAVE (Oral Clinical Trials for Tofacitinib in Ulcerative Colitis) program have met their primary endpoints. At week 8, a significantly greater proportion of patients receiving tofacitinib (Xeljanz, Pfizer) 10 mg twice daily (BID) were in remission compared with patients…
Researchers funded by the National Institutes of Health (NIH) have discovered the cellular switch that boosts the activity of sperm cells so that they can travel to the egg. The finding may lead to new options for male contraception as well as treatments for infertility resulting from problems with…
Surgery has been the standard treatment for appendicitis for more than a century. Millions of appendectomies are performed annually in the world, more than 300,000 in the U.S. alone. Studies have been carried out over the years to determine whether nonperforated appendicitis could be treated with antibiotics…
When mutated, a gene known for its ability to repair DNA appears instead to cause breast cancer, scientists report. The gene, GT198, whether mutated by genetics, environmental factors, or both, has strong potential as a way to diagnose breast cancer early and as a new treatment target, said Dr. Lan…
 Scientists at Umeå Centre for Microbial Research (UCMR) have discovered chemical compounds that are able to attenuate the virulence of the bacterial human pathogen Listeria monocytogenes. Their findings were published in Cell Chemical Biology. The dramatic increase of antibiotic resistance makes…
Treatment with ustekinumab (Stelara, Janssen) induced clinical response and clinical remission in adult patients with moderate-to-severe Crohn's disease who had previously failed or were intolerant to treatment with one or more anti-tumor necrosis factor (TNF)-alpha therapies, according to phase 3 data…
A new study demonstrates that mindfulness meditation works on a different pain pathway in the brain than opioid pain relievers. The researchers noted that because opioid and nonopioid mechanisms of pain relief interact synergistically, the results of this study suggest that combining mindfulness-based…
Key factors that can combine to produce a Zika virus outbreak are expected to be present in a number of U.S. cities during peak summer months, new research shows. The Aedes aegypti mosquito, which is spreading the virus in much of Latin America and the Caribbean, will likely be increasingly abundant…
Amid disappointing sales, Takeda Pharmaceuticals U.S.A. has cancelled its collaboration agreement with Orexigen Therapeutics for the commercialization of Contrave (naltrexone/bupropion), an obesity treatment. Takeda announced that it would refocus its resources on drug launches in the antidepressant…
One in four seniors is bringing along stowaways from the hospital to their next stop: so-called “superbugs” on their hands. Moreover, seniors who go to a nursing home or another post-acute care facility will continue to acquire new superbugs during their stay, according to findings made by researchers…
The FDA has approved Kovaltry, Bayer AG’s therapy for the most common form of hemophilia, approximately three weeks after it was cleared for use in Europe. Kovaltry (antihemophilic factor [recombinant]), a prophylactic infusion administered two or three times a week, is indicated for use in adults…

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